Gregory L Holmes Selected Research

Flurothyl (Flurotyl)

1/2021	Effects of early life seizures on coordination of hippocampal-prefrontal networks: Influence of sex and dynamic brain states.
12/2019	Segregation of seizures and spreading depolarization across cortical layers.
5/2015	Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide.
9/2013	Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex.
10/2011	Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex.
6/2011	Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures.
4/2010	Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex.
12/2009	Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex.
9/2009	Recurrent seizures induce a reversible impairment in a spatial hidden goal task.
6/2009	Early life seizures cause long-standing impairment of the hippocampal map.

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Gregory L Holmes Research Topics

Disease

73	Seizures (Absence Seizure) 01/2022 - 01/2002
32	Epilepsy (Aura) 02/2022 - 06/2002
18	Status Epilepticus (Complex Partial Status Epilepticus) 01/2017 - 01/2002
13	Cognitive Dysfunction 02/2022 - 08/2003
5	Epileptic Syndromes 01/2018 - 01/2002
4	Infantile Spasms (West Syndrome) 08/2014 - 01/2002
4	Tuberous Sclerosis (Bourneville's Disease) 09/2011 - 03/2002
2	Temporal Lobe Epilepsy 01/2017 - 09/2002
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 06/2013 - 01/2013
1	Dizziness (Lightheadedness) 06/2020
1	Headache (Headaches) 06/2020
1	Fatigue 06/2020
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 04/2020
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2019
1	Disease Progression 06/2018
1	Multiple Sclerosis 01/2018
1	Crohn Disease (Crohn's Disease) 01/2018
1	Gliosis 01/2018
1	Neuroinflammatory Diseases 01/2018
1	Brain Diseases (Brain Disorder) 01/2017
1	Convulsions benign familial neonatal dominant form 12/2016
1	Coma (Comas) 01/2014
1	Autistic Disorder (Autism) 06/2013
1	Alzheimer Disease (Alzheimer's Disease) 06/2013
1	Ischemia 03/2013
1	Hypoxia (Hypoxemia) 03/2013
1	Absence Epilepsy (Childhood Absence Epilepsy) 08/2012
1	Malformations of Cortical Development 06/2011
1	Febrile Seizures (Febrile Seizure) 01/2009
1	Sudden Unexpected Death in Epilepsy 12/2008
1	Shock 03/2008

Drug/Important Bio-Agent (IBA)

22	Anticonvulsants (Antiepileptic Drugs)IBA 06/2018 - 06/2002
16	Flurothyl (Flurotyl)IBA 01/2021 - 08/2003
14	Pilocarpine (Ocusert)FDA LinkGeneric 01/2017 - 01/2002
10	Pharmaceutical PreparationsIBA 01/2021 - 03/2002
8	LithiumIBA 01/2017 - 10/2002
7	gamma-Aminobutyric Acid (GABA)IBA 10/2009 - 01/2002
6	Biomarkers (Surrogate Marker)IBA 02/2022 - 01/2009
5	Biological ProductsIBA 01/2022 - 07/2013
5	Neuroprotective AgentsIBA 01/2017 - 10/2002
4	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2016 - 01/2002
4	Topiramate (Topamax)FDA LinkGeneric 01/2009 - 03/2002
4	Kainic Acid (Kainate)IBA 10/2003 - 01/2002
3	N-Methylaspartate (NMDA)IBA 01/2013 - 01/2002
3	ChloridesIBA 10/2009 - 04/2005
3	Lamotrigine (Lamictal)FDA LinkGeneric 12/2008 - 03/2002
3	GABA-A Receptors (GABA(A) Receptor)IBA 12/2007 - 10/2005
3	Diazepam (Valium)FDA LinkGeneric 01/2007 - 08/2003
2	Carbamazepine (Tegretol)FDA LinkGeneric 06/2020 - 12/2016
2	PlasticsIBA 10/2014 - 12/2009
2	Sodium Channels (Sodium Channel)IBA 06/2013 - 12/2007
2	PotassiumIBA 11/2012 - 01/2007
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2012 - 04/2010
2	N-Acetylneuraminic Acid (Sialic Acid)IBA 03/2011 - 10/2007
2	UridineIBA 07/2008 - 07/2006
2	Pentylenetetrazole (Metrazol)IBA 03/2008 - 10/2002
2	isoguvacineIBA 01/2007 - 10/2005
2	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 06/2005 - 10/2002
2	Glutamic Acid (Glutamate)FDA Link 11/2002 - 10/2002
1	ElementsIBA 01/2021
1	eslicarbazepine acetateIBA 11/2020
1	Lacosamide FDA Link 06/2020
1	SiliconesIBA 12/2019
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2018
1	Granzymes (Granzyme)IBA 01/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018
1	IntegrinsIBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	PAR-1 ReceptorIBA 01/2017
1	Hormones (Hormone)IBA 01/2016
1	Bumetanide (Bumex)FDA LinkGeneric 05/2015
1	Isoflurane FDA LinkGeneric 01/2014
1	Anesthetics (Anesthetic Agents)IBA 01/2014
1	ConvulsantsIBA 09/2013
1	Small Interfering RNA (siRNA)IBA 06/2013
1	Hyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIBA 03/2013
1	ElectrolytesIBA 08/2012
1	SodiumIBA 08/2012
1	Thrombin FDA Link 08/2012
1	Voltage-Gated Sodium ChannelsIBA 03/2012
1	Everolimus FDA Link 09/2011
1	Tuberous Sclerosis Complex 1 ProteinIBA 09/2011
1	Tuberous Sclerosis Complex 2 ProteinIBA 09/2011
1	Sirolimus (Rapamycin)FDA Link 09/2011
1	Methylazoxymethanol AcetateIBA 06/2011
1	Neuraminidase (Sialidase)IBA 03/2011
1	Sialic AcidsIBA 01/2011
1	Neurotransmitter Receptors (Neurotransmitter Receptor)IBA 10/2009
1	Saline SolutionIBA 01/2009
1	T-Type Calcium Channels (T-Type Calcium Channel)IBA 12/2007
1	CalciumIBA 12/2007
1	Indicators and Reagents (Reagents)IBA 06/2007

Therapy/Procedure

19	Therapeutics 01/2021 - 03/2002
2	Electrodes (Electrode) 01/2018 - 08/2014
2	Ketogenic Diet 03/2004 - 03/2002
1	Induced Hypothermia 01/2019
1	Rewarming 01/2019
1	Hemispherectomy 01/2018
1	Injections 03/2011
1	Continuity of Patient Care 10/2010